Warning Signs of Estrogen Toxicity in Dogs

Warning Signs of Estrogen Toxicity in Dogs—What to Watch For

Estrogen toxicity in dogs happens when there's too much estrogen (a female sex hormone) in the body, either from an internal source or from external medication. This condition is most commonly seen in female dogs of breeding age and older male dogs.

This toxicity can be caused by tumors that produce estrogen or by estrogen-like drugs, which are sometimes used to treat various conditions in dogs, like prostate disease, anal tumors, or urinary incontinence (a lack of bladder control).

Symptoms of Estrogen Toxicity in Dogs

Signs that your dog might have estrogen toxicity include:

Lethargy
Pale gums (usually due to anemia)
Bleeding from the skin, in the urine, stool, or from vomiting
Fever
Recurring or persistent infections
Hair loss
Males developing female characteristics

Diagnosing Estrogen Toxicity in Dogs

To diagnose estrogen toxicity in dogs, veterinarians use various tests to find the source of the estrogen and determine its effects. Here are some common tests:

Complete Blood Count (CBC): This test measures red blood cells and platelets. In estrogen toxicity, these counts usually drop, while white blood cells might stay the same or increase. In later stages, even white blood cells can decrease.
Bone Marrow Aspiration and Cytology: This test examines bone marrow to confirm low cell counts.
Abdominal X-rays and Ultrasound: These can help detect tumors that might be producing estrogen.
Testicular Examination in intact male dogs.

Treating Estrogen Toxicity in Dogs

The treatment for estrogen toxicity involves:

Removing the source of the estrogen
Providing supportive care
Giving blood transfusions to dogs with severe anemia
Using antibiotics for secondary infections due to low white blood cell counts

Home Care and Prevention

Follow your veterinarian's instructions carefully for any prescribed medications.

Keep a close eye on your dog for any changes in their condition, as recovery from estrogen toxicity can take several weeks to a few months.

Most importantly, do not give your dog estrogen-containing substances unless specifically directed by your vet.

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